Myosin heads bind to actin filaments to cause movement and force via contractions. “Hypercontractions” can result if messaging dysfunction leads to hyperactivity of the acto-myosin system.

Pathological “hypercontraction” is a leading cause of morbidity in various disease states and conditions. Without an effective treatment for skeletal- and smooth-muscle myosin hypercontractions, millions of patients suffer with consequent disabilities.