Pathological skeletal muscle hypercontraction occurs when abnormal neural activity drives excessive muscle contraction or when normal relaxation signals fail.

It is a major feature of stroke, brain injury, multiple sclerosis, cerebral palsy, ALS, stiff-person syndrome, epilepsy, essential tremor and Parkinson’s disease.

These sustained contractions cause pain, loss of mobility and independence, and severe physical and social disability.

More than 50% of patients discontinue current muscle relaxants because of insufficient efficacy or neurological side effects, leaving millions of people to live with disabling hypercontraction for years or even lifelong without effective treatment.

PeriFlow acts differently: our drugs target the contractile machinery directly, releasing pathological contraction without suppressing the nervous system.

Moderately spastic patient
after stroke

PeriFlow’s skeletal muscle myosin inhibitors fully resolve muscle spasticity without affecting normal physical activity.